منابع مشابه
Kiss of death
Kiss of death D8 cytotoxic T cells are serial killers that slay one infected or cancerous cell after another. During each fatal encounter, an intercellular junction called the immunological synapse forms between killer and victim, according to researchers from Oxford University (Oxford, UK). Their work suggests new functions for the immunological synapse and supports the hypothesis that the imm...
متن کاملThe kiss of death.
The kiss of death Cellular suicide is a grave matter, motivating researchers to a thorough exploration of the genetic pathways involved. Of the three main means by which cells die, most in the scientific community are quite familiar with the genetically regulated apoptotic pathway (1). Autophagy, in which the cell literally digests itself, is likewise now also recognized as a form of regulated ...
متن کاملThe Kiss of Death
The programmed cell death (PCD) of neurons is generally thought to be cell autonomous and not to require a death signal from other cells. A recent study by Marín-Teva et al., in this issue of Neuron, brings this theory into question and suggests that neighboring microglia actively participate in the PCD of Purkinje cells in the cerebellum.
متن کاملThe CTL's kiss of death
The potent and specific lytic activity of CTLs can occur by at least two distinct pathways. In the secretion and perforin-mediated pathway, the direct effect(s) on the target cell membrane of the pore-forming agent perforin, probably in conjunction with granzymes, also secreted from the CTLs, causes the target's demise. Intercytoplasmic transfer of granzymes is believed to be involved in induci...
متن کاملAtrial fibrillation: A kiss of death?
Atrial fibrillation (AF) is frequently encountered in acute ST-elevation myocardial infarction (STEMI) as well as in elderly patients, and is the most common cardiac arrhythmia in general. Its incidence increases with age and above 80 years it affects approximately 8 % of patients [1]. However, the clinical and prognostic significance depends on the setting in which it occurs. The most likely p...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2001
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1556rr4